Objective：To investigate the expression of blood routine related indicators in acute and chronic spontaneous urticaria and its clinical
significance. Methods：The blood routine test was  measured in 178 patients with acute urticaria，118 patients with chronic urticaria and 119 healthy people. The differences among  the third groups were compared. Results：The WBC， NEUT， MONO and NLR were significantly higher in acute urticaria group than those in the chronic urticaria group and the control group (P＜0.05) The PLT and PLR in the acute urticaria group was significantly lower than the chronic urticaria group and the control group (P＜0.05). The LY and SII were significantly higher in acute urticaria group than those in the control group (P＜0.05)， and the BASO were significantly lower in acute urticaria group than those in the control group (P＜0.05)，but there was no significant difference between the acute urticaria group and the chronic urticaria group (P＞0.05).The WBC， NEUT， LY, and MONO were significantly higher in chronic urticaria group than those in the control group (P＜0.05). The PLR in the chronic urticaria group was significantly lower than the control group (P＜0.05). There was no significant difference between the chronic urticaria group and the control group for the EOS，PLT,BASO,MPV,NLR,SII  (P＞0.05). The AUC of ROC curve of WBC,NEU,MONO were 0.734,0.701,0.709,respectively.Conclusion：The WBC,NEU and MONO of the patients with urticaria could be used for provide more reference for clinical diagnosis and treatment of urticaria.

Objective：To explore the relationship between serum immunoglobulin E (IgE) and eosinophil (EOS) and different types of allergic skin diseases. Methods:Eighty cases of allergic dermatosis and 80 cases of health examination respectively were enrolled in the observation group and the control group. Fasting venous blood was collected and serum total IgE and EOS levels were measured. The results were compared and analyzed.Results:The levels of serum IgE and EOS in the observation group were significantly higher than those in the control group, and the positive rates of serum IgE and EOS were also significantly higher (P<0.05). There were significant differences in serum IgE level, EOS count, IgE positive rate and EOS positive rate among different types of allergic skin diseases (P<0.05). Serum IgE level, EOS count, IgE positive rate and EOS positive rate were the  lowest  in allergic purpura group, while they   were the highest  in eczema group.  There was no significant correlation between serum IgE and EOS counts in patients with allergic dermatosis (r=0.16, P>0.05). Conclusion:The occurrence of allergic skin diseases is related to the high expression of serum IgE and EOS. The expression of serum IgE and EOS in different types of allergic skin diseases is significantly different. The clinical treatment plan of immunoglobulin should be reasonably formulated according to the expression characteristics of serum IgE and EOS in allergic skin diseases.

Objective：To investigate the efficacy and safety of pregabalin in the treatment of postherpetic neuralgia in the elderly. Methods:Sixtytwo patients with postherpetic neuralgia in our department were randomly divided into observation group (32 cases) and control group (30 cases). The control group received routine treatment, oral mecobalamin capsules and vitamin B1 tablets, three times a day, one tablet for once, for 2 weeks. The observation group was given orally with pregabalin capsule on the basis of the control group, the initial dose was 75 mg twice a day.If the pain control was not satisfactory, the dosage could be increased to 150 mg twice a day, or   reduced appropriately according to the degree of pain relief after taking the drug.The course of treatment was  2 weeks. The VAS, DLQI score and adverse reactions were observed before treatment, in the first week and the second week after treatment. Results:The VAS and the DLQI score in the first week and in the second week after treatment in the observation group were lower than those before treatment, and the difference was statistically significant (P＜0.01). The VAS  and the DLQI score in the second week decreased more significantly than those in the first week (P＜0.05). The VAS and  the DLQI score in the control group in the first week and in  the second week after treatment had no significant difference compared with those before treatment (P＞0.05). The patients in the observation group had adverse reactions such as drowsiness, dizziness, dry mouth and constipation,but none of them affected the treatment. No other obvious adverse reactions was observed in the two groups. Conclusion:Pregabalin is safe and effective in the treatment of postherpetic neuralgia in the elderly.

Objective：To improve the level of syphilis serology test in the laboratory of   medical institutions for the treatment of venereal diseases
in Shaoguan city of Guangdong province    by evaluating the serological quality of syphilis, and to analyze the choice of serological test methods and the accuracy of testing methods of various laboratories. Methods: One hundred and fortytwo   laboratories of medical institutions in Shaoguan  city for the treatment of sexually transmitted diseases were selected, and the diagnostic technique and quality control training courses for sexually transmitted diseases were held in 2018. Each laboratory distributed five syphilis serological quality control products. The examination content included three kinds of test items: qualitative and quantitative test of nonspecific antibodies of syphilis, and qualitative test of syphilis specific antibodies. The laboratoies were  required to conduct tests within a specified time and report the results through the network. Results: Of the 39 sexually transmitted diseases laboratories passed  the  evaluation of  the sexually transmitted diseases laboratory, 34 had excellent quality evaluation(≥90 points) accounting for 8718%; 5 good(75~<90 points)  accounting  for 12.82%. The pass rate of the 39 nonsyphilis spiral serolog  (NTT) and syphilis spiral serology(TT) laboratories assessed for sexually transmitted diseases was both 100%, and the compliance rate of dection method was 100%, 97.14%, respectively.  Of  103 laboratories failed the evaluation, 63  participated in NTT,the assessment rate was 57.14%, and the compliance rate of dection method was 53.97%. 69 laboratories participated in the TT assessment, with a  assessment   rate of  53.62% and a compliance rate of 73.91%.  The  assessment rate (  x ²=22.73、21.60， both P<0.01 ) and the   compliance rate(  x ²=376.26、142.65, both P<0.01)   of NTT quantitative test and TT quantitative in the laboratories passed the evaluation were significantly higher than that in laboratories failed the evaluation.  Conclusion:The results of the assessment of interroom quality of venereal disease laboratory in Shaoguan city in 2018  are superior to those of laboratories that have not passed the evaluation and there are many problems in those laboratories.  It is necessary to pay attention to strengthen the quality management of syphilis test and improve the level of testing.

Objective：To understand the use of condoms in outpatients with gonorrhea in Guangdong Province and explore its influencing factors, so as to provide basis for relevant decisionmaking departments to formulate intervention measures.Methods：Through crosssectional survey, gonorrhea patients with sexual contact history for nearly 6 months were recruited in 21 prefecturelevel cities of Guangdong Province. The  information of general demographic characteristics and sexual behavior were collected. The influencing factors of condom use were analyzed by singlefactor and multifactor logistic regression. Results:A total of 1 695 patients   were included in the study. The average age was (31.17±9.86) years. The condom use rate of gonorrhea patients who had sex with commercial partner, spouse/fixed partner and nonfixed noncommercial partner was 80.39%, 64.25% and 69.11%, respectively, and the difference was statistically significant (  x ²=48.99,P<0.01). Multivariate logistic regression showed: age, the level of education, marital status, and past HIV infection/venereal history are the influencing factors of condom use. Conclusion:The use of condoms in gonorrhea patients is low, and the use rate of sexual relationship with spouses is the lowest. Low educational level, no previous HIV infection/venereal history are the risk factors for not using condoms. Therefore, it is necessary to strengthen the intervention of such people and reduce the spread of sexually transmitted diseases such as gonorrhea.