Leprosy, an important public health issue, can impose serious health and economic burden on migrant population. However, there is no unified management plan for migrant patients with leprosy in Guangdong province. Through exploration and practice, we developed this consensus on the management of migrant patients with leprosy. The management plan includes the case detection and management, institutional responsibility and quality control. According to the different types of the medical institutions at the time of case diagnosed, leprosy prevention institutions where patient lives, other medical institutions where patient lives, and non-local medical institutions, the medical institutions should carry out the following measures according to the corresponding responsibility: collection of patients' information, report of the case, referral when needed, entry into the specialized disease system, treatment, follow-up, rehabilitation services, and moving in or out. The establishment of this management plan will help standardize the case management of migrant patients with leprosy, reduce the disease burden, protect the health of the people, and also provide guidance and reference for the leprosy prevention and control in other provinces or regions.

Objective To investigate the role of ASPN in the development of keloid and the underlying mechanisms. Methods Immunofluorescence staining was used to assess the expression levels of ASPN in keloid of keloid patients and normal scar. WB and qRT-PCR were used to assess the activity of TGF-β pathway and expression levels of α-SMA、Collagen Ⅰ/Ⅲ, COMP and POSTN in fibroblasts with overexpression of ASPN, ASPN-treated fibroblasts and Keloid fibroblasts with ASPN knockdown. Moreover, wound healing was observed in C57BL/6J mice treated with or without ASPN at 0 d,3 d,7 d,and 14 d after wound. The expression levels of α-SMA、Collagen Ⅰ/Ⅲ and TGF-β in the wounded skin were assessed by immunofluorescence staining 14 days after wound. Results ASPN was highly expressed in keloid fibroblasts. The expression levels of α-SMA、Collagen Ⅰ/Ⅲ、COMP and POSTN were significantly increased, and the TGF-β signaling pathway was activated in fibroblasts after either overexpression of or stimulation with ASPN(P<0.05). In contrast, knockdown of ASPN significantly decreased the expression levels of α-SMA、Collagen Ⅰ/Ⅲ, COMP and POSTN and inhibited TGF-β pathway in fibroblasts from keloids(P<0.05). In addition, ASPN significantly increased the expression levels of p-SMAD2、α-SMA and Collagen Ⅰ and activated TGF-β signaling pathway in the wound area(P<0.05 vs. controls), without altering the wound healing process. Conclusion ASPN promotes the development of keloid by activating TGF-β signaling pathway.

Objective To analyze urogenital Mycoplasma hominis (Mh) and Ureaplasma urealyticum (Uu) infections and drug sensitivity, providing a rationale for choosing antibiotics in clinical practice. Methods Clinical data were collected from 296 patients with Mycoplasma infections who visited the First Hospital of Putian City from September 2022 to August 2023. The patients'age, gender and the clinical symptoms were analyzed. Urogenital specimen from patients was cultured for isolation and identification of Uu and Mh. Results Among 256 women and 40 men with mycoplasma infections, patients aged 31~40 years old accounted for 40.54%. The rate of Mycoplasma infections did not differ significantly between males and femlaes among all age groups (all P>0.05). Over 55% of the patients with Mycoplasma infections had clinical symptoms (X²=5.68,P<0.05 vs. no symptoms). Patients with Uu and Mh infections were 238 cases (80.41%) and 5 cases (1.69%), respectively. Fifty-three cases (17.91%) were infected with both Mh+Uu. The positive rates of Uu and Uu+Mh infections were significantly higher in female patients than in male patients (=11.27, =10.09, P<0.05). In Mh positive patients, Mh was sensitive to both doxycycline and minocycline with a sensitive rate of 100%, but resistant to erythromycin and ciprofloxacin. In Mh+Uu positive patients, the sensitivity rates of doxycycline, minocycline and josamycin were over 90%, but resistant to erythromycin. In Uu positive patients, the sensitivity rates of doxycycline and minocycline were 100% and 99.58%, respectively, and the resistance rate of ciprofloxacin was 76.90%. Conclusions Females are more likely to have urogenital tract mycoplasma infections than males, and Uu is the main pathogen. The three types of infections are sensitive to doxycycline and minocycline. In clinical practice, the choosing antimicrobial drugs should be based on the type of infection and the sensitivity to the drugs.

Objective To report a case of Nagashima-type palmoplantar keratoderma(NPPK), identify pathogenic gene, and assist clinical diagnosis and classification of this disease. Methods Clinical data of the patient were collected. Genomic DNA was extracted from the patient's peripheral blood sample. Whole exome high-throughput sequencing was used to identify the pathogenic mutation, and Sanger sequencing was applied to verify the mutation site. Results Heterozygous mutations of c.455G>T(p.Gly152Val)and c.796C>T(p.Arg266Ter)were found in the patient. The patient's father was a heterozygous carrier of the mutation c.455G>T without the c.796C>T mutation, and his mother was a heterozygous carrier of the mutation c.796C>T without the c.455G>T mutation. Together with the clinical manifestations of diffuse erythema on the palms and toes since childhood, the patient was diagnosed with NPPK. Conclusions The c.455G>T and c.796C>T heterozygous mutations in the SERPINB7 gene are the pathogenic cause of NPPK in this patient. The diagnosis and disease type of the patient are clarified, and genetic counseling is provided according to the patient's request.

Objective To explore the application of Kano model management combined with standardized skin care in preventing incontinence-associated dermatitis in patients with acute stroke. Methods Ninety patients with acute stroke admitted to the First Affiliated Hospital of Xiamen University from January to December 2021 were divided into two groups using a random number table method. The control group (45 cases) received routine care, while the observation group (45 cases) received the Kano model management in combination with standardized skin care. Nursing care was given to both groups until discharge. The incidence of incontinence-associated dermatitis, quality of life, and the degree of satisfaction were compared between the two groups. Results The incidence of incontinence-associated dermatitis was significantly lower in the observation group (8.89%) than in the controls (35.55%)(X²=9.26,P=0.002). Moreover, the Kolcaba Comfort Scale (GCQ) scores in all dimensions were higher in the observation group than in the control group (all P<0.001). In addition, newcastle satisfaction with nursing scale was higher in the observation group (95.56%) than in the control group (82.22%) (X²=4.05,P=0.044). Conclusions The combination of Kano model management and standardized skin care can effectively prevent the development of incontinence-associated dermatitis and improve patients' comfort and satisfaction scales of the patients' family members in subjects with acute stroke.

Objective Using network pharmacology and molecular docking techniques to analyze the molecular mechanisms of active ingredients of ginseng in the treatment of atopic dermatitis. Methods The databases of OMIM, TTD, CTD, GEO and GeneCards were used to screen the homologous targets and disease targets of active ingredients in ginseng. Then the ″drug-component-target″ network was constructed, and the potential and core targets of ginseng for the treatment of atopic dermatitis were screened. GO functional enrichment and KEGG pathway analysis were performed on the overlapping targets of active ingredients in ginseng and AD. Finally, the binding ability of active ingredients to TOP4 core targets was verified through molecular docking, and the docking results were visualised. Results A total of 22 active ingredients and 106 targets were identified. The GO functional enrichment showed that the biological processes were mainly involved in inflammatory response and regulation of secretion, etc., while the molecular function was mainly involved in the binding of nuclear receptor and cytokine receptors, etc. Among the cellular components, receptor complex and membrane rafts accounted for a large proportion. KEGG enrichment analysis identified 156 signaling pathways, including IL-17, TNF and other signaling pathways. Molecular docking results showed that all of the active compounds of ginseng had low binding energy to the TOP4 core targets, among which arachidonate, panaxadiol and stigmasterol had very high affinity to the core target IL-1β. Conclusions Ginseng has the potential to treat atopic dermatitis. Arachidonate, panaxadiol and stigmasterol may be the key monomeric components of ginseng for the treatment of AD, and they probably play a therapeutic role through interacting with IL-1β.

Dermatovenereology is a multidisciplinary and interdisciplinary subject. In exploration of modern teaching models, the inquiry-based teaching model is proved to assist students in accurately and efficiently mastering the disciplinary knowledge which they have learned on the basis of giving full play to their subjective initiative, and its significance for this discipline is self-evident. This paper systematically expounds the practical value of the inquiry-based teaching model from multiple aspects such as connotation, characteristics, and significance. It is reasonable to believe that the inquiry-based teaching model, as one of the modern teaching models, can effectively help students understand, master, and apply knowledge in practice, truly enabling them to grow through learning, to improve through practice, and to apply what they have learned.

We report a case of superficial angiomyxoma. A 25-year-old man presented with a subcutaneous mass on the left neck for one year. Dermatological examination showed a subcutaneous nodule with firm texture and moderate mobility on the neck. The ultrasound examination showed a hypoechoic area without obvious blood flow signals. Histological examination showed a mass composed of fibers, blood vessels and spindle cells, accompanied by extensive myxoid degeneration. Immunohistochemical staining showed positive for vimentin and CD34. The diagnosis was superficial angiomyxoma. Complete surgical excision was performed, and no recurrence was observed during 6-month follow-up.

We report successful treatment of a case with acute graft-versus-host disease. A 54-year-old male presented with a fever for two weeks and generalized pruritic erythemas for three days. The patient had allogeneic liver transplantation one month ago. Dermatological examination revealed lip erosion with purulent discharge, multiple erythematous rashes on the head, face, trunk, and extremities. Normal skin islands could be seen between some erythemas, and both palms had targetoid erythema. A surgical scar approximately 35 cm in length was observed below the rib margin. Histopathological changes included extensive epidermal necrosis with satellite lymphocytic infiltration surrounding necrotic keratinocytes in the epidermis, subepidermal clefts, mild perivascular lymphocytic infiltration in the superficial dermis, focal necrosis of follicular epithelium, and a few lymphocytic infiltrations around sweat glands. A diagnosis of acute graft-versus-host disease was made. The patient was treated with high dose glucocorticoids and human immunoglobulin. The treatments improved both erythema and other conditions, and the patient was discharged. No new lesions or liver transplant rejection occurred during 4-month follow-up.

Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphomas. Most cases of MF progress slowly with a good prognosis. However, some early-stage patients may still experience disease progression with a poor prognosis. Immunohistochemical (IHC) staining is a commonly used diagnostic method in clinical practice. Common markers such as CD4, CD8, CD20, and CD30 have different expression patterns in mycosis fungoides. In addition, these markers can also be used to evaluate the degree of disease progression and prognosis. In-depth research on immunohistochemical markers helps better understand the pathogenesis of MF and provides a more accurate basis for clinical treatment, such as guiding the selection of treatment regimens and evaluating treatment effects, in addition to its indispensable role in the clinical management of MF. This article reviews the role of IHC markers in the diagnosis and prognosis of MF and explores the application value of different molecular marker patterns.

Photodynamic therapy (PDT) is a highly selective, non-invasive treatment of diseased tissue with cosmetic benefit, and is one of the first choice for the treatment of local solar keratosis. However, PDT has a longer single treatment time, possibly causing adverse reactions such as local erythema and itching. This paper mainly reviews recent advances in the application of PDT in the treatment of AK, such as combining with different light sources, shortening incubation and light exposure time, and pre-preparation, in order to provide a better choice in clinical practice.

Scars, the final outcome of postoperative wound healing, can be classified into physiological scars and pathological scars. Following surgical procedures, dysregulation of the inflammatory response, abnormal mechanical forces surrounding the wound, and hypoxia within the scar tissue may lead to an overproliferation of fibroblasts in postoperative scars, resulting in excessive deposition of extracellular matrix and ultimately developing pathological scars. The emergence of pathological scars does not only negatively impact patients' physical and mental well-being, but also significantly diminishes their quality of life. Because of the big challenge in the treatment of scars, early intervention strategies, such as vascular sealing, modulation of inflammatory factors, and tension reduction, can expedite the maturation process of postoperative scars while decreasing the incidence of pathological scars. This paper aims to overview the methods and mechanisms for early intervention of postoperative scars, including intraoperative tension reduction suture, reduction in postoperative pressure and injection therapy, laser, and topical medication, in order to provide valuable insights for related therapeutic approaches.