银屑病样表现的移植物抗宿主病1例

doi:10.3969/j.issn.1674-8468.2022.03.012.

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皮肤性病诊疗学杂志 ›› 2022, Vol. 29 ›› Issue (3) : 253-256. DOI: 10.3969/j.issn.1674-8468.2022.03.012.

病例研究

银屑病样表现的移植物抗宿主病1例

黄锦萍¹，温炬¹ ，李婷¹，秦思¹，周玉婵²，郑荣昌¹

作者信息 +

A case of psoriasiform graftversushost disease

HUANG Jinping¹, WEN Ju1, LI Ting¹, QIN Si¹, ZHOU Yuchan², ZHENG Rongchang¹

Author information +

文章历史 +

摘要

报告1例罕见的银屑病样表现的移植物抗宿主病。患者女，35岁，头面部、四肢伸侧、躯干出现红色斑块，上覆银白色鳞屑。患者患急性B淋巴细胞白血病1年余，9个月前行异基因造血干细胞移植术。Auspitz^，s阳性。组织病理同时具备银屑病样和界面皮炎样改变。免疫组化CD4⁺T细胞、CD8⁺T淋巴细胞浸润。诊断：银屑病样移植物抗宿主病。外用0.1%他克莫司软膏治疗1周后,皮损明显消退。

Abstract

A rare case of psoriasiform graft-versus-host disease is reported. The patient suffered from acute B-cell leukemia for more than 1 year. Nine months after allogenic hematopoietic stem cell transplantation, the patient developed red papules and plaques, with Auspitz sign positive and silver-white scales on the head, face, limb and trunk. The histopathology showed both psoriatic and interfacial dermatitis. Immunohistochemical staining demonstrated infiltration of CD4⁺and CD8⁺ T cells. Diagnosis was psoriasiform graftversushost disease. Lesions were improved by topical 0.1% tacrolimus ointment.

导出引用

黄锦萍1，温炬1,李婷1，秦思1，周玉婵2，郑荣昌1. 银屑病样表现的移植物抗宿主病1例[J]. 皮肤性病诊疗学杂志, 2022, 29(3): 253-256 https://doi.org/10.3969/j.issn.1674-8468.2022.03.012.

HUANG Jinping1, WEN Ju1, LI Ting1, QIN Si1, ZHOU Yuchan2, ZHENG Rongchang1. A case of psoriasiform graftversushost disease[J]. Diagnosis and Therapy Journal of Dermato-Venereology, 2022, 29(3): 253-256 https://doi.org/10.3969/j.issn.1674-8468.2022.03.012.

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